Uncovering Mysteries of Marine Life through Marine Chemicals
The oceans cover over 70% of our planet and are home to countless life forms that still remain undiscovered. Through the use of blue biotechnology, scientists are hoping to unlock some of the hidden treasures found in the seas. By harnessing molecules, enzymes and genetic material from marine organisms, researchers are working to develop new medicines, foods, and industrial materials.
Exploring Untapped Resources for Marine Chemicals
As biotechnologists explore the oceans, they are discovering an abundance of bioactive compounds produced by marine organisms that have pharmaceutical potential. Sponges, corals, molluscs, microbes and other creatures have evolved unique chemical defenses to survive in their habitats. Many of these secondary metabolites show promise for treating human diseases like cancer, Alzheimer's, inflammation and more. Some examples include ziconotide from cone snails which is used as a non-opioid painkiller, and trabectedin from sea squirts approved for sarcoma treatment. Through culturing symbiotic microbes and genomic analysis of marine species, scientists aim to tap this reservoir of "blue drugs" to develop new therapies.
Unraveling the Blue Genome
With advances in DNA sequencing, researchers can now study the genomes of marine organisms to better understand their biology and adaptations. Marine Chemicals Genome mining is revealing how creatures like seaweeds, corals and sponges produce a stunning diversity of useful metabolites. It also provides insights into their stress tolerance, photo/chemo-syntheses and symbiotic relationships. This genomic data is being databased and analyzed to identify genes and pathways involved in making novel natural products. Comparing genomes across species also sheds light on marine evolution and ecology. It paves the way for future synthetic biology approaches to recreate ocean-inspired functionalities in sustainable systems on land.
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