Essential traditional patch-clamp methods for studying cellular electrophysiology have limited throughput and demand a high level of experimental skill. Although automated patch-clamp (APC) methods provide high throughput and greater researcher independence, they are mostly restricted to tests with small, homogenous cells by design. We used a fixed-well APC plate architecture to enable high-throughput APC tests on bigger cells, such as native cardiomyocytes isolated from mammalian hearts.

Unveiling the Intricacies of Cellular Function

At the heart of every biological process lies the fundamental behavior of individual cells. The Automated Patch Clamp System provides researchers with the means to scrutinize these cellular dynamics with unparalleled detail. By precisely controlling the membrane potential and recording ion channel activity, scientists can unravel the complex mechanisms underlying neuronal signaling, cardiac function, and beyond. This level of insight not only expands our understanding of basic physiology but also holds profound implications for disease research and drug development.

Enhancing Efficiency and Accuracy

Traditionally, patch clamping—a technique used to study the electrical properties of cells—has been a labor-intensive and time-consuming process. However, the Automated Patch Clamp System streamlines this procedure, automating many of the repetitive tasks while maintaining high data quality. By significantly reducing experimental variability and increasing throughput, researchers can accelerate their investigations and achieve more robust results in a fraction of the time previously required.

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