Tacrolimus monohydrate
Tacrolimus, also known as FK506, is a fermentation product isolated from Streptomyces. It is a macrolide antibiotic. It is a powerful new immunosuppressant. It comprehensively inhibits the function of T lymphocytes mainly by inhibiting the release of interleukin-2 (IL-2), which is 100 times stronger than cyclosporine (CSA). In recent years, as a first-line drug for liver and kidney transplantation, it has been listed in 14 countries such as Japan and the United States. Clinical experiments show that it has a good effect in heart, lung, intestine and bone marrow transplantation. At the same time, FK506 also plays an active role in the treatment of autoimmune diseases such as atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and so on.
1.The mechanism of action of tacrolimus
Tacrolimus is a potent immunosuppressant. The mechanism of action is similar to cyclosporine, but the clinical efficacy is better than cyclosporine. Inhibits T-cell activation and inhibits T-cell-dependent B-cell proliferation. It also inhibits the production of lymphokines such as interleukin-2, interleukin-3 and gamma-interferon and the expression of interleukin-2 receptor.
2. Precautions for the use of tacrolimus
(1) The adverse reactions of tacrolimus include: neurotoxicity, nephrotoxicity, drug-induced liver injury, hyperkalemia, diabetes, abnormal blood sugar, anemia and other drug improvement.
(2) During tacrolimus treatment, blood drug concentration and biological indicators should be monitored regularly. Once adverse reactions occur, the attending physician should be notified in time, and the drug should not be stopped or reduced arbitrarily.
(3) During the use of tacrolimus, visual and neurological impairment may occur due to neurotoxicity, so it is not recommended to drive or operate dangerous machinery. At the same time, this effect may be aggravated by alcohol consumption, which should be avoided after taking tacrolimus.
(4) Tacrolimus cannot be used in combination with cyclosporine to avoid excessive suppression of the immune system.
Tacrolimus Monohydrate Suppliers - Minbiotch
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